NCT06574152 Effect of Photobiomodulation on Pain and Healing of Vertical Releasing Incision After Endodontic Microsurgery. Overall status Recruiting; Location: University of Texas Health Science Center at Houston, Houston, Texas, USA. Contacts: Juliana Barros, DDS, MS फोन 713-486-4564 email Juliana.Barros@uth.tmc.edu; Kala Morales फोन 713-486-4229 email Kala.D.MoralesLadrondeGuevara@uth.tmc.edu. Intervention: Device PBM (photobiomodulation) therapy 660 nm diode laser 50 mW 25 ثانية 10 J/cm² energy after apical microsurgery; sham comparator. Mechanism: лазеr stimulates कोश cellular ऊर्जा, anti-inflammatory and wound healing at surgical incision reducing pain.

 

NCT07469150 Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment. Overall status Not yet recruiting; Location: University of Alabama at Birmingham, Birmingham, Alabama. Contacts: Can Wang, PhD 205-934-1141 email cw24@uab.edu; Ashraf F Fouad, DDS, MS 205-934-5373 email afouad@uab.edu. Intervention: Root canal disinfection GentleWave System (multisonic/ultrasonic NaOCl and EDTA irrigation under negative pressure after minimal instrumentation) versus conventional rotary instrumentation with passive ultrasonic irrigation using NaOCl. Mechanism: GentleWave multisonic cavitation improves irrigation dynamics, debris/biofilm disruption, bacterial load reduction in root canal system; compared to standard rotary/PUI.

 

NCT06776289 Endodontic Microsurgery. Overall status Not yet recruiting; Location: University of Kentucky College of Dentistry Endodontics Division, Lexington, Kentucky. Contacts: Mark Schachman, DMD 8593238575 email mark.schachman@uky.edu; Dawn Dawson, RDH, CCRC 8593235409 email ddaws1@uky.edu; Michael Skanchy, DMD 859-562-2232 email msk232@uky.edu. Intervention: Endodontic microsurgery (apicoectomy) with platelet-rich fibrin (PRF) biological graft placed in osteotomy versus microsurgery alone. Mechanism: PRF is autologous fibrin matrix rich in platelets/leukocytes growth factors to accelerate bone and soft tissue healing and reduce postoperative pain; microsurgery removes apical संक्रमण lesion and seals root-end.