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  1. [
  2.   {
  3.     "nctId": "NCT05266040",
  4.     "title": "Valacyclovir in Pain Management of Acute Apical Abscesses",
  5.     "status": "RECRUITING",
  6.     "statusDate": {
  7.       "date": "2025-05-30",
  8.       "type": "ACTUAL"
  9.     },
  10.     "conditions": [
  11.       "Acute Apical Abscess",
  12.       "Pain, Acute"
  13.     ],
  14.     "interventions": [
  15.       {
  16.         "type": "DRUG",
  17.         "name": "Valacyclovir 500 MG",
  18.         "description": "Consistent with the pilot study VEII will use a random number generator to randomly assign a Manila packet containing amoxicillin 500mg + Valtrex (valacyclovir 500mg x three times daily for 7 days). Opaque medication packaging and using standardized verbal and written instructions helps ensure blindness of the VEII calibrated clinician, and patients of the therapeutic group they were assigned to.",
  19.         "armGroupLabels": [
  20.           "valacyclovir group"
  21.         ]
  22.       },
  23.       {
  24.         "type": "DRUG",
  25.         "name": "Placebo",
  26.         "description": "Consistent with the pilot study VEII will use a random number generator to randomly assign a Manila packet containing amoxicillin 500mg + Placebo (empty capsule). Opaque medication packaging and using standardized verbal and written instructions helps ensure blindness of the VEII calibrated clinician, and patients of the therapeutic group they were assigned to.",
  27.         "armGroupLabels": [
  28.           "Control group"
  29.         ]
  30.       }
  31.     ],
  32.     "contacts": [
  33.       {
  34.         "name": "Mike Sabeti, DDS",
  35.         "role": "CONTACT",
  36.         "phone": "415-476-0822",
  37.         "email": "Mike.Sabeti@ucsf.edu"
  38.       }
  39.     ],
  40.     "locations": [
  41.       {
  42.         "facility": "UCSF Dental",
  43.         "status": "RECRUITING",
  44.         "city": "San Francisco",
  45.         "state": "California",
  46.         "zip": "94143",
  47.         "country": "United States",
  48.         "contacts": [
  49.           {
  50.             "name": "mike sabeti, DDS",
  51.             "role": "CONTACT",
  52.             "phone": "415-476-0822",
  53.             "email": "mike.sabeti@ucsf.edu"
  54.           }
  55.         ],
  56.         "geoPoint": {
  57.           "lat": 37.77493,
  58.           "lon": -122.41942
  59.         }
  60.       }
  61.     ]
  62.   },
  63.   {
  64.     "nctId": "NCT06574152",
  65.     "title": "Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery",
  66.     "status": "RECRUITING",
  67.     "statusDate": {
  68.       "date": "2024-08-29",
  69.       "type": "ACTUAL"
  70.     },
  71.     "conditions": [
  72.       "Apical Periodontitis",
  73.       "Endodontically Treated Teeth",
  74.       "Endodontic Disease",
  75.       "Apical Cyst",
  76.       "Apical Granuloma",
  77.       "Periradicular Disease",
  78.       "Previous Endodontic Treatment"
  79.     ],
  80.     "interventions": [
  81.       {
  82.         "type": "DEVICE",
  83.         "name": "PBM treatment",
  84.         "description": "Immediately after the apical microsurgery, PBM therapy will be performed using a 660 nm diode laser (SiroLaser Advance Plus, Dentsply Sirona Inc, Charlotte, North Carolina, USA), with an 8 mm tip diameter . The laser tip will be placed following the outline of the incision flap in a contact mode . The power output of the laser will be 50 milliwatt (mW) and verified by a Power Meter (PM600 Power/Energy meter, Molectron Detector Inc, Portland, OR, USA). Each site will be irradiated for 25 s with an energy density of 10 J/cm2",
  85.         "armGroupLabels": [
  86.           "EMS and PBM treatment"
  87.         ]
  88.       },
  89.       {
  90.         "type": "DEVICE",
  91.         "name": "PBM sham treatment",
  92.         "description": "Immediately after the apical microsurgery, sham therapy will be performed without activating the laser.",
  93.         "armGroupLabels": [
  94.           "EMS and PBM sham treatment"
  95.         ]
  96.       },
  97.       {
  98.         "type": "DEVICE",
  99.         "name": "EMS",
  100.         "description": "Patients will be anesthetized. All surgeries will be performed using a surgical microscope. After reflection of a mucoperiosteal flap, osteotomies will be performed to access the root apices and apical lesions. Root apices will be resected at 3 mm, and the pathological tissue curetted out. Next, root-end preparations will be made with ultrasonic tips and filled with calcium silicate-based materials. Methylene blue dye will be used for inspection after root-end resection before the root-end preparation and filling. After cleaning the osseous crypt, the wound margins will be reapproximated with 5-0 single interrupted sutures. A gauze will be placed for 30 minutes for wound compression. Sutures will be removed seven days postoperatively",
  101.         "armGroupLabels": [
  102.           "EMS and PBM sham treatment",
  103.           "EMS and PBM treatment"
  104.         ]
  105.       }
  106.     ],
  107.     "contacts": [
  108.       {
  109.         "name": "Juliana Barros, DDS,MS",
  110.         "role": "CONTACT",
  111.         "phone": "(713) 486-4564",
  112.         "email": "Juliana.Barros@uth.tmc.edu"
  113.       },
  114.       {
  115.         "name": "Kala Morales",
  116.         "role": "CONTACT",
  117.         "phone": "713-486-4229",
  118.         "email": "Kala.D.MoralesLadrondeGuevara@uth.tmc.edu"
  119.       }
  120.     ],
  121.     "locations": [
  122.       {
  123.         "facility": "The University of Texas Health Science Center at Houston",
  124.         "status": "RECRUITING",
  125.         "city": "Houston",
  126.         "state": "Texas",
  127.         "zip": "77030",
  128.         "country": "United States",
  129.         "contacts": [
  130.           {
  131.             "name": "Juliana Barros, DDS, MS",
  132.             "role": "CONTACT",
  133.             "phone": "713-486-4564",
  134.             "email": "Juliana.Barros@uth.tmc.edu"
  135.           },
  136.           {
  137.             "name": "Kala Morales",
  138.             "role": "CONTACT",
  139.             "phone": "713-486-4229",
  140.             "email": "Kala.D.MoralesLadrondeGuevara@uth.tmc.edu"
  141.           }
  142.         ],
  143.         "geoPoint": {
  144.           "lat": 29.76328,
  145.           "lon": -95.36327
  146.         }
  147.       }
  148.     ]
  149.   },
  150.   {
  151.     "nctId": "NCT07469150",
  152.     "title": "Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment",
  153.     "status": "NOT_YET_RECRUITING",
  154.     "statusDate": {
  155.       "date": "2026-03-13",
  156.       "type": "ACTUAL"
  157.     },
  158.     "conditions": [
  159.       "Apical Periodontitis"
  160.     ],
  161.     "interventions": [
  162.       {
  163.         "type": "PROCEDURE",
  164.         "name": "GentleWave System",
  165.         "description": "Minimally invasive root canal disinfection using the GentleWave multisonic irrigation system following minimal instrumentation. The system delivers multisonically activated sodium hypochlorite and EDTA solutions under negative pressure to enhance irrigation dynamics and debris removal within the root canal system during nonsurgical endodontic retreatment.",
  166.         "armGroupLabels": [
  167.           "GentleWave Disinfection Group"
  168.         ]
  169.       },
  170.       {
  171.         "type": "PROCEDURE",
  172.         "name": "Conventional rotary instrumentation with passive ultrasonic irrigation",
  173.         "description": "Conventional nonsurgical endodontic retreatment using nickel-titanium rotary instrumentation followed by passive ultrasonic irrigation (PUI). Irrigation is performed using sodium hypochlorite delivered via a side-vented needle and ultrasonically activated irrigation to enhance canal disinfection after mechanical preparation.",
  174.         "armGroupLabels": [
  175.           "Conventional Rotary Instrumentation with Passive Ultrasonic Irrigation"
  176.         ]
  177.       }
  178.     ],
  179.     "contacts": [
  180.       {
  181.         "name": "Can Wang, PhD",
  182.         "role": "CONTACT",
  183.         "phone": "205-934-1141",
  184.         "email": "cw24@uab.edu"
  185.       },
  186.       {
  187.         "name": "Ashraf F Fouad, DDS, MS",
  188.         "role": "CONTACT",
  189.         "phone": "205-934-5373",
  190.         "email": "afouad@uab.edu"
  191.       }
  192.     ],
  193.     "locations": [
  194.       {
  195.         "facility": "University of Alabama at Birmingham",
  196.         "city": "Birmingham",
  197.         "state": "Alabama",
  198.         "zip": "35233",
  199.         "country": "United States",
  200.         "contacts": [
  201.           {
  202.             "name": "Can Wang, PhD",
  203.             "role": "CONTACT",
  204.             "phone": "2059341141",
  205.             "email": "cw24@uab.edu"
  206.           },
  207.           {
  208.             "name": "Ashraf F Fouad, DDS,MS",
  209.             "role": "CONTACT",
  210.             "phone": "205-934-5373",
  211.             "email": "afouad@uab.edu"
  212.           },
  213.           {
  214.             "name": "Can Wang, PhD",
  215.             "role": "PRINCIPAL_INVESTIGATOR"
  216.           },
  217.           {
  218.             "name": "Ashraf F Fouad, DDS, MS",
  219.             "role": "SUB_INVESTIGATOR"
  220.           }
  221.         ],
  222.         "geoPoint": {
  223.           "lat": 33.52066,
  224.           "lon": -86.80249
  225.         }
  226.       }
  227.     ]
  228.   },
  229.   {
  230.     "nctId": "NCT06776289",
  231.     "title": "Endodontic Microsurgery",
  232.     "status": "NOT_YET_RECRUITING",
  233.     "statusDate": {
  234.       "date": "2026-01-16",
  235.       "type": "ACTUAL"
  236.     },
  237.     "conditions": [
  238.       "Apical Periodontitis"
  239.     ],
  240.     "interventions": [
  241.       {
  242.         "type": "BIOLOGICAL",
  243.         "name": "Platelet rich fibrin",
  244.         "description": "Platelet rich fibrin will be used to fill an osteotomy after endodontic microsurgery is completed.",
  245.         "armGroupLabels": [
  246.           "Microsurgery with Platelet Rich Fibrin"
  247.         ]
  248.       }
  249.     ],
  250.     "contacts": [
  251.       {
  252.         "name": "Dawn Dawson, RDH, CCRC",
  253.         "role": "CONTACT",
  254.         "phone": "8593235409",
  255.         "email": "ddaws1@uky.edu"
  256.       },
  257.       {
  258.         "name": "Michael Skanchy, DMD",
  259.         "role": "CONTACT",
  260.         "phone": "859-562-2232",
  261.         "email": "msk232@uky.edu"
  262.       }
  263.     ],
  264.     "locations": [
  265.       {
  266.         "facility": "University of Kentucky College of Dentistry Endodontics Division",
  267.         "city": "Lexington",
  268.         "state": "Kentucky",
  269.         "zip": "40508",
  270.         "country": "United States",
  271.         "contacts": [
  272.           {
  273.             "name": "Mark Schachman, DMD",
  274.             "role": "CONTACT",
  275.             "phone": "8593238575",
  276.             "email": "mark.schachman@uky.edu"
  277.           },
  278.           {
  279.             "name": "Dawn Dawson, RDH, CCRC",
  280.             "role": "CONTACT",
  281.             "phone": "8593235409",
  282.             "email": "ddaws1@uky.edu"
  283.           }
  284.         ],
  285.         "geoPoint": {
  286.           "lat": 37.98869,
  287.           "lon": -84.47772
  288.         }
  289.       }
  290.     ]
  291.   }
  292. ]

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